关键词: 生存预后, BORIS, 免疫组织化学, 胃癌

Abstract: ［Abstract］ Objective Brother of regulator of imprinted sites （BORIS） was a DNA-binding protein that was normally expressed in the testes and associated with some kinds of tumor malignancy. The aims of the present study was aimed to investigate BORIS expression in gastric cancer （GC） and found out the prognostic value of this proteins. Methods Using immunohistochemical staining， BORIS expression was studied to assess potential correlation between BORIS expression in GC following radical surgery with clinicalpathological parameters and overall survival in this study. Survival analysis was performed and compared using Kaplan?Meier curves， Life?table， log?rank test， and Cox regression analysis. Results BORIS expression was significantly higher in GC tissues than in normal adjacent tissues. In 63.1% （41 of 65 cases） BORIS was observed in stomach tumors. BORIS expression was associated with tumor invasion， lymph node metastasis and advanced TNM stage. Furthermore， those patients with BORIS positive had worse survival outcome compared with the ones with BORIS negative （5?year survival rate： 22.0% vs 49.8%， P=0.009）. Univariate Cox regression analysis revealed that BORIS expression was a prognostic parameter in out study. Conclusion BORIS was a promising indicators for predicting clinicopathological features and prognosis in GC cases.

Key words: prognosis, BORIS, gastric cancer, immunohistochemistry