关键词: 结直肠癌, 益生菌, 肠道菌群, 加速康复外科

Abstract: ［Abstract］ Objective To investigate the effect of enhanced recovery after surgery combined with probiotics on intestinal microflora in patients with colorectal cancer after operation. Methods From May 2016 to May 2018， 126 patients with colorectal cancer were prospectively enrolled in the gastrointestinal surgery department of Jiangmen Central Hospital. According to the random number table method， the patients were divided into control group （59 cases， ERAS group） and experimental group （67 cases， ERAS combined with probiotics treatment group）. The changes of intestinal floras in different genus and the grading of intestinal floras disorder were compared between the two groups. The incidence of complications related to intestinal infection was compared between the two groups. Results Dysbacteriosis were happened before operation in both groups （P>0.05）. The majority of patients in the control group were Ⅱ° dysbacteriosis after operation， while those in the experimental group were mainly I°dysbacteriosis after operation （P=0.014）. The total number of bifidobacteria and lactobacillus in the experimental group was higher than that in the control group （P<0.001）. The incidence of diarrhea， abdominal infection and anastomotic leakage in the control group was higher than that in the experimental group， but only the incidence of diarrhea had significant difference between the two groups， while the incidence of abdominal infection and anastomotic leakage had no significant difference. There was no sepsis after operation in both groups. Conclusions Perioperative probiotic therapy for colorectal cancer patients can improve the intestinal microecological environment， protect the intestinal mucosal barrier and accelerate the recovery of patients.

Key words: probiotics, colorectal cancer, intestinal floras, enhanced recovery after surgery