关键词: 骨质疏松性腰椎体压缩性骨折, 老年女性, 经皮穿刺椎体后凸成形术, 骨水泥

Abstract: ［Abstract］ Objective To investigate the effects of different doses of bone cement PKP combined with estrogen on postmenopausal women with osteoporotic lumbar vertebral compression fracture. Methods 120 elderly female patients with osteoporotic lumbar vertebral compression fractures admitted to our hospital from January 2015 to June 2018 were divided into three groups （group A 2~4 ml， group B 4~5 mL， group C 5~4 mL） according to the dosage of bone cement injected during PKP operation. All patients were followed up for one year and compared with the third group after operation. The VAS score， ODI score， the anterior height of injured vertebral body， the middle height of vertebral body and the incidence of complications were recorded. Results There was no significant difference in VAS score and ODI score between the three groups before treatment （P>0.05）； at the follow?up of three days and one year after operation， all the indexes of the three groups were significantly improved compared with those before treatment （P<0.05）， and there was no significant difference between the three groups （P>0.05）. There was no significant difference in the anterior and middle height of vertebral body before treatment （P>0.05）； the anterior and middle height of vertebral body increased significantly after three days and one year follow?up （P<0.05）. The anterior height of vertebral body in group C>group B>group A， and the intervertebral height in group C>group B were significantly higher than that before treatment （P<0.05）. The incidence of complications in group A （12.5%） was significantly lower than that in group B （30.0%） and group C （41.0%） （P<0.05）. Conclusion Intraoperative injection of low dose bone cement （2~4 ml） in PKP is effective and safe for the treatment of OVCFs in elderly women.

Key words: bone cement, elderly women, osteoporotic lumbar vertebral compression fracture, percutaneous kyphoplasty