关键词: 围术期, 腹腔镜, 阑尾切除, 抗生素应用持续时间, 并发症, 发生率

Abstract: Objective To analyze the effect of perioperative duration of antibiotic use on the incidence of complications in patients undergoing laparoscopic appendectomy. Methods 836 patients with laparoscopic appendectomy from July 2012 to June 2017 in our hospital were analyzed retrospectively， and the patients were divided into 3 groups according to different duration of antibiotics：186 patients as group A treated with antibiotics for less than 2 days after postoperation，404 as group B treated with antibiotics for 2-4 days，and 246 as group C treated with antibiotics for more than 4 days. The wound infection and incidence of diarrhea by using antibiotic were compared between the 3 groups. Results The proportions of patients with surgical incision achieving grade A healing were 77.96% ，76.24% and 80.89%，respectively，and the difference among group A，group B and group C was not significant（P> 0.05）. The infection rate of wound incision in the three groups was 2.69%，1.98% and 2.44%. There was no significant difference in the infection rate between the three groups （P>0.05）. However，antibiotic userelated diarrhea increases with prolonged use of antibiotics. Conclusion Perioperative duration of antibiotic use in patients undergoing laparoscopic appendectomy has no significant effect on the incidence of wound infection，but prolonged use increases the incidence of antibiotic?associated diarrhea in patients.

Key words: complications, laparoscopic, perioperative period, appendectomy, duration of antibiotic application, incidence