关键词: 结直肠非特异性炎症, 肿瘤分期, 结直肠癌, 结直肠癌

Abstract: ［Abstract］ Objective The aim is to identify the influence of non?specific colorectal inflammation on colorectal cancer and its clinical significance. Methods This study was a retrospective cohort study by reviewing colorectal cancer patients from the Sixth Affiliated Hospital of Sun Yat?sen University from 2007 to 2010. All patients with preoperative colonoscopy data or surgical pathology confirmed enteritis were included in the study ；divided into inflammation group（enteric endoscopy and surgical pathology enteritis）and control group；comparison of tumor stage, lymph node metastasis, cancer nodule metastasis Other surgical pathological data and survival prognosis indicators；follow?up of overall survival and tumor recurrence, followed up for 3 years. Results A retrospective study of 907 patients included 346 patients. Among them, 70 cases were in the inflammation group, including 39 cases of distant enteritis（20.2%）, and 16 cases of tumor?in situ enteritis. 22.9%）, 15 cases（21.4%）with surgical pathology and 276（78.8%） in the control group. In the inflammatory group, the tumor incidence rate was 74.3%（P<0.001）, lymph node metastasis rate was 62.3%（P<0.001）, and cancer nodule metastasis rate was 40.2%（P=0.001）. Logistic regression analysis showed that surgical pathology enteritis was an independent risk prognostic factor for advanced tumors（P=0.016）, lymph node metastasis（P=0.017）, and cancer nodule metastasis（P=0.017）. Prostate distant enteritis was independent risk prognostic factors for advanced tumor （P= 0.003）and lymph node metastasis（P=0.017）. Conclusion There is a clear correlation between non?specific inflammation of the colorectal before surgery and the staging of the tumor. Such cases can be used to study the relationship between colorectal inflammation and malignant tumors.

Key words: colorectal cancer, colorectal non?specific inflammation, tumor stage, colorectal cancer