关键词: 环状RNA, 结直肠癌

Abstract: ［Abstract］ Colorectal cancer（CRC）is the third most common malignancy in the world and the fourth leading cause of cancer-related deaths. Circular RNAs are novel long-chain non? coding RNAs that are widely present in eukaryotes and are spliced by a variety of mechanisms. Early circular RNAs were ignored as a by?product of gene expression and had no biological function. Recent studies have confirmed that circular RNAs play an indispensable role in many life activities and that abnormal expression in CRC tissues plays a significant role in proliferation，invasion，metastasis and apoptosis of the tumor cells. Exploring the mechanism of action of the circular RNA in colorectal cancer will contribute to the early diagnosis，treatment and prognosis of CRC. This article will focus on the latest research progress of circular RNA in colorectal cancer，thus providing new ideas for the diagnosis and treatment of CRC.

Key words: colorectal cancer, circular RNAs