关键词: 脑电双频指数, 氟马西尼, 全麻肝叶切除术, 促醒, 认知功能

Abstract: ［Abstract］ Objective To observe the revival effects of flumazenil in patients undergoing hepatic lobectomy under general anesthesia and the influence on convalescent bispectral index （BIS） and cognitive function. Methods Fifty patients undergoing hepatic lobectomy under general anesthesia were selected. They were divided into flumazenil group（n=25）and non flumazenil group（n=25）according to the use of flumazenil. Both groups were given remifentanil combined with propofol target-controlled infusion（TCI）general anesthesia，and BIS was maintained between 40 to 60. At the end of the operation， the flumazenil group was given intravenous infusion of flumazenil，and the non flumazenil group was given intravenous injection of equal volume of normal saline. Postoperative recovery time and changes of BIS values at different time points after recovery in the two groups were recorded. The cognitive function of patients was evaluated by the mini mental state examination（MMSE）before operation and at 1 d，3 d and 5 d after operation. Results The postoperative spontaneous breathing recovery time，eye opening time under the instruction，fist making time under the instruction，extubation time and time of recalling the birth date of the flumazenil group were significantly shorter than those of the non flumazenil group （P< 0.05）. The BIS value of the flumazenil group increased significantly at 4 min after entering the anesthesia recovery room（P<0.05），while the BIS value of the non flumazenil group increased significantly at 6 min after entering the anesthesia recovery room（P<0.05）. The BIS values the flumazenil group at 4 min，6 min，8 min，10 min，12 min，14 min and 16 min after entering the anesthesia recovery room were significantly higher than those of the non flumazenil group（P<0.05）. MMSE scores of the flumazenil group at 1 d，3 d and 5 d after operation were significantly higher than those of the non flumazenil group（P< 0.05）. Conclusion Flumazenil can promote the recovery of patients undergoing hepatic lobectomy from general anesthesia and improve their cognitive function.

Key words: revival, bispectral index, hepatic lobectomy under general anesthesia, cognitive function, flumazenil