关键词: 锁定钢板, 骨形态发生蛋白, 骨折不愈合, 股骨干骨折, 髓内钉

Abstract: Objective To investigate the clinical effect of morphogenetic protein bone（BMP）in the treatment of femoral shaft fractures in children. Methods Twenty-eight cases of pediatric femoral shaft fractures were treated with cases of pediatric femoral shaft fractures from January 2012 to June 2016 in our hospital, and 16 cases were treated with locking plate and BMP, and 12 cases were treated with elastic intramedullary nailing. The amount of blood loss, operation time, hospitalization time, hospitalization expenses and postoperative exercise time were observed in the two groups. After 1 year follow-up, X-ray film was observed. Results all cases achieved bony union, and no loosening was found in X- ray findings. The average healing time of the observation group was 3.89±0.28 months, the control group was 3.82±0.25 months, the difference was not statistically significant（P>0.05）in the two groups. There was no fracture nonunion or delayed union in the follow- up period. There were no complications such as infection, necrosis of the femoral head, hip, and hypotension in the two groups. There was no significant difference in the amount of bleeding, hospitalization time, hospitalization expenses and postoperative exercise time in the two groups（P>0.05）；the control group was significantly different from the control group （P<0.05）. Conclusion The locking plate combined with autologous cancellous bone, bone morphogenetic protein in the treatment of femoral shaft fractures in children can improve the fracture healing rate, reliable fixation, less complications, and can be used in clinical application.

Key words: intramedullary nailing, bone morphogenetic protein, femoral shaft fractures, locking plate, fracture nonunion