关键词: 特异性富AT序列结合蛋白1, 平滑肌肌动蛋白-α, 胰腺癌

Abstract: Objective To investigate the expression level and clinical significance of special AT-rich sequence binding protein 1（SATB-1）and α-smooth muscle actin（α-SMA）in pancreatic cancer. Methods Immunohistochemical staining was performed to analyze the expression of SATB- 1 and α- SMA in 71 pancreatic cancer tissue, the clinicopathological features were collected, and the clinical relationship between the SATB-1 and α-SMA expression and clinicopathological features. Results The positive expression rate of SATB- 1 and α- SMA was 70.4% and 77.5%, respectively. Kaplan- Meier analysis showed that the expression levels of SATB-1 and α-SMA was relative with overall survival time of pancreatic cancer patients. Cox regression analysis showed that differentiation and SATB- 1 expression were independent prognosis factors of pancreatic cancer patients. Chi- square test showed that SATB- 1 expression was relative with the expression of α- SMA（P<0.05）. Conclusion SATB- 1 and α- SMA was over- expressed in pancreatic cancer, and SATB- 1 deserved as an independent prognosis factor of pancreatic cancer.

Key words: SATB-1, α-SMA, pancreatic cancer