关键词: 乳腺癌, 支链氨基酸氨基转移酶 1, 预后

Abstract: Objective To investigate the expression level and prognostic value of branched- chain amino acid transferase- 1（BCAT1）in breast cancer. Methods We retrospectively analyzed the specimens of 74 patients with breast cancer who underwent radical mastectomy from 2009 to 2010 in our Department. Immunohistochemistry assay was carried out to assess the protein expression levels of BCAT1 in breast cancer and the adjacent normal tissue. The relationship between BCAT1 expression and clinical parameters and survival outcome were also studied. Result According to theimmunohistochemistry assay，the expression of BCAT1 protein in breast cancer was significantly higher than that in adjacent normal breast tissues（68.9% vs 35.0% ，P<0.05）. Moreover，the high BCAT1 group had higher percentages of advanced T stage，lymph node metastasis，advanced TNM stage and larger tumor size compared with the ones in the low BCAT1 group （χ2=6.228，6.894，7.415，6.210 respectively，all P values <0.05）. The overall 5-year survival rate in the high and low BCAT1 group was 56.9% and 82.6% and thelog-rank test revealed that the survival outcome in the low BCAT1 group was significantly better than the one in the high BCAT1 group（χ2=5.209，P<0.05）. Conclusion BCAT1 protein expression was elevated in breast cancer. Moreover，the high expression of BCAT1 expression was positively associated with tumor size，lymph node metastasis and survival outcome. BCAT1 may be a potential target of breast cancer.

Key words: breast cancer, prognosis, branched-chain amino acid transferase-1