关键词: 重型急性脑梗死, 定量脑电监测, 临床预后 , α变异百分率

Abstract: Objective To analyze the correlation between percent alpha variability and clinical prognosis in patients with severe actue cerebral infarction after 90 days，and evaluate its clinical practical value of the clinical prognosis. Methods Thirty- one patients with severe actue cerebral infarction were accepted continuous brain function monitoring and clinical diagnosis and treatment. All patients in group were accepted the continuous 72 hours of continuous brain function monitor，and were recorded the average of Percent Alpha Variability which admitted to hospital 24 h ，48 h ，72 h. And scored the NIHSS，GCS，CNFD when admitted to hospital ，and 90 days after onset. According to the clinical prognosis ，the patients were divided into good and poor prognosis groups，and the correlation between Percent Alpha Variability and clinical prognosis were analyzed in patients with severe actue cerebral infarction after 90 Days. Results The Percent Alpha Variability was associated with the affected hemisphere. The Percent Alpha Variability of affected hemisphere is lower than the no- affected hemisphere. Between good prognosis and poor prognosis groups，there were significant differences of the score of the percent alpha variability in the hospital within 0-24 h，24-48 h，48-72 h. Spearman analysis indicated the percent alpha variability in the hospital within 0-24 h，24-48 h，48-72 h were positive correlated with good prognosis. The percent alpha variability in the hospital within 0-24 h，24-48 h，48-72 h predicted good prognosis. The sensitivity and specificity of good prognosis would be high when the percent alpha variability≥20%. The sensitivity of the percent alpha variability in the hospital within 0-24 h，24-48 h，48~72 h was 68.4% ，63.25，63.2% ，and the specificity was 66.7% ，75.0% ，91.7% . Conclusion The percent alpha variability of affected hemisphere in the hospital within 72 h was positively correlated with good prognosis in severe acute cerebral infarction. To some extent ，the percent alpha variability could predict the clinical prognosis of severe acute cerebral infarction.

Key words: clinical prognosis, severe actue cerebral infarction , Percent Alpha Variability, Quantitative ElectroEncephaloGram