关键词: 胃癌, 恶病质, 白介素-6 , 抵抗素

Abstract:

Objective To observe the changes of serum resistin level in patients with gastric cancer associated-cachexia and to investigate the relationship between resistin and interleukin-6（IL-6）. Methods Twenty-three cases of gastric cancer patients with cachexia were assigned to the cachexia group; 23 cases of gastric cancer patients without cachexia were used as the gastric cancer group; and 23 healthy people were taken as normal controls. All the subjects were tested the sex, age, BMI and pathologic stages of cancer. The serum levels of IL-6, resistin were detected by enzyme-linked immunoabsorbent assay （ELISA）. Results Patients with pathologic stages Ⅲ and Ⅳwere more susceptible to cachexia than those with pathologic stages Ⅰ and Ⅱ in gastric cancer（P< 0.05）. Compared with control group, the serum resistin level and IL-6 were significantly increased in the cathexia group and gastric cancer group（P<0.05）. Along with pathological stage increasing, the serum resistin level were significantly increased. Serum resistin level was positive correlated with IL-6 in the cachexia group（r = 0.512, P = 0.012）. Conclusion Along with pathological stage increasing in gastric cancer, the serum levels of resistin and IL-6 were significantly increased. Serum resistin and IL-6 were increased in the cathexia patients. And serum resistin was positively correlated with interleukin-6 in gastric cancer cachexia.

Key words: resistin, IL-6, gastric cancer, cachexia