关键词: T 细胞亚群 , 人类乳头瘤病毒, 尖锐湿疣, 细胞因子, 细胞免疫

Abstract:

 Objective To investigate the changes of cytokines and immune function in patients with recurrent condyloma acuminatum. Methods A total of 87 patients with condyloma acuminatum were included in this study, and were assigned to two groups, primary group（n=48）, recurrent groups （n=39）. Another 42 healthy subjects were selected as controls （control group）. The peripheral blood levels of CD4+ T?lymphocyte, CD8+ T?lymphocyte, CD4+/CD8+ ratio and the levels of IL-2, IL?4, IL?6 were detected and analyzed statistically. Results There were significant differences in the levels of IL ?2, IL?4, IL?6, CD4+ T?lymphocyte, CD8+?T lymphocyte, CD4+/CD8+ ratio between the three groups（all P values were less than 0.05）. Serum IL?2, IL?6, CD4+/CD8+ ratio in the patients with relapse were sig-nificantly lower than those in the control group（all P values were less than 0.05）. There was no signifi-cant difference in serum IL?2, IL?4, IL?6, CD4+, CD8+, CD4+/CD8+ levels between the initial group and the control group（all P values were more than 0.05）. Conclusion In patients with recurrent condylo-ma acuminatum, there is an imbalance of cellular immune function, and this cellular immune dysfunc-tion may be a cause of recurrent attacks

Key words: cytokines, cellular immunity, human papillomavirus, T cell subsets, condyloma acuminata