关键词: 结直肠癌, 分离富集, 临床意义, 循环肿瘤细胞

Abstract: Although the efficacy of surgery，chemotherapy and radiotherapy in colorectal cancer has been greatly improved in recent years ，15%-20% of patients with colorectal cancer had hepatic me? tastases when they were first diagnosed ，and 60% of the rest experienced metastatic or recurrent tumors. As a focus of clinical research in recent years ，circulating tumor cells have the tremendous potential in evaluating curative effect and prognosis. This article reviews the separation enrichment techniques ，detec? tion techniques and clinical significance of circulating tumor cells in colorectal cancer.

Key words: colorectal cancer, circulating tumor cells, clinical significance, separation enrichment techniques