关键词: 前哨淋巴结转移, 乳腺肿瘤, 非前哨淋巴结转移

Abstract: 【Abstract】 Objective To evaluate the correlation between non?sentinel lymph nodes（nSLN） metastasis and clinic?pathologic features in primary breast cancer patients with 1 or 2 sentinel lymph nodes（SLN） metastasis. Methods Retrospectively analyzed clinical and pathological data of 118 primary breast cancer patients with 1 or 2 positive sentinel lymph nodes and axillary lymph nodes dissection in The 2nd Affiliated Hospital of Guangzhou Medical University. Chi-square test and Logistic regression were used for univariate and multivariate analysis separately. Results 45.8%（54/118）of all patients with positive non?sentinel lymph nodes metastasis. Univariate analysis revealed nSLN metastasis was associated with tumor size, intravascular tumor thrombus and ratio of SLN metastasis（all P values less than 0.05）. Multivariate analysis showed that tumor size , intravascular tumor thrombus and ratio of SLN metastasis were independent influencing factors of nSLN metastasis（OR=3.159, 2.425, 2.258, all P values less than 0.05）. Conclusion In 1 or 2 positive SLN breast cancer patients with tumor size≥2 cm, intravascular tumor thrombus or ration of SLN metastasis≥2/3 are prone to have metastasis in nSLN.

Key words: metastasis, sentinel lymph nodes metastasis, non?sentinel lymph nodes, breast neoplasms