关键词: 丙泊酚, Narcotrend 麻醉指数, 右旋美托咪定, 警觉/镇静评分

Abstract: 【Abstract】 Objective To compare the correlation between narcotrend index（NTI）and OAA/ S in patients undergoing surgery under epidural?spinal anesthesia sedated with dexmedetomidine and propofol. Methods Sixty patients who were going to receive elective lower abdominal surgery or lower extremity surgery under epidural?spinal anesthesia, ASA Ⅰ ～Ⅱ, were divided into two groups, respectively group dexmedetomidine （group D, n=30）and group propofol（group P, n=30）. After the EA anesthesia level became stable and the anesthesia effect ensured, drugs were administered using computer?controlled infusions targeting an plasma concentration of 0.6, 1.2, 2.4 ng · mL- 1 for dexmedetomidine or effect?site concentration 1、2、4 μg · ml- 1 for propofol. The relationship between NTI and OAA/S score was obtained 20 min after changing each drug concentration. Results NTI at OAA/S scores of 5，4，3，2，1 during propofol sedation were 96（89-97），83（86-82），66（63-71），57（50-61）， 46（40-50），respectively. NTI at OAA/S scores of 5，4，3，2，1 during dexmedetomidine sedation were 94 （78-98），79（83-75），45（45-52），38（34-41），24（20-30），respectively. Conclusion The combination of both NTI and OAA/S score could different to the clinicion evaluating the patient′s response to sedation than would either tool alone，especially when dexmedetomidine is used.

Key words: oaa/s, propofol, narcotrend index, dexmedetomidine