关键词: 左乳内动脉, 动物模型 , 冠状动脉旁路移植术

Abstract: 【Abstract】 Objective To establish a pig model for simulating the left internal mammary artery bypass graft in video?assisted off?pump coronary artery bypass graft and compared with median thoracotomy operation. Methods Sixteen pigs were randomly divided into two groups, VACAB Group （n=8）and MTCAB Group（n=8）. The former was performed video?assisted coronary artery bypass graft with left internal mammary artery-left anterior descending（LIMA-LAD）. The animals in MTCAB Group were subjected to median thoracotomy for coronary artery bypass graft with LIMA-LAD. Operation time, harvest time of left internal mammary artery（LIMA）and LIMA- LAD anastomosis time were compared between the two groups. And the levels of creatinine kinase （CK），creatinine kinase isoenzyme （CK- MB），and troponin I（cTnl）in different time points were recorded and compared between two groups. Results The operation time，the harvest time of LIMA and LIMA- LAD anastomosis time of VACAB group were longer than that of group MTCAB, and the differences were statistically significant. There was no significant difference in LIMA bridge flow between the two groups. The differences of CK, CK- MB and cTnI between the two groups were not statistically significant. Conclusion Video-assisted coronary bypass was a practical and effective method of minimally invasive direct coronary bypass graft. VACAB training by using the animal model is helpful to clinical practice

Key words: left internal mammary artery, animal model, coronary artery bypass graft