关键词: 皮肤, 经皮穴位电刺激, 乳腺癌 , 强啡肽

Abstract: 【Abstract】 Objective To observe the effect of transcutaneous electrical acupoint stimulation (TEAS) on the dynorphin expression of skin incision in breast cancer patients. Methods Eighty?three female patients with breast cancer scheduled to perform surgery were randomly assigned to sufentanil group (group 1, n=28), sufentanil plus TEAS with sparse waves group (group 2, n=25), sufentanil plus TEAS with encryption waves group (Group 3, n=30). Under monitoring of Narcotrend index (Ni), regulation of propofol target controlled infusion injection concentration. All the three groups were given sufentanil 0.3~0.4 μg/kg, cisatracurium 2~3 mg/kg. At the beginning and end of operation, the edge of skin incision tissue (0.5 cm × 1 cm) was taken for detection of dynorphin expression using immunohistochemically. Results All the dynorphin expression at the end of operation were significantly higher than that of the beginning (P<0.01), but no difference among the three groups (P>0.05). Conclusion Surgical stimulation increases the dynorphin expression of skin incision in breast cancer patients. TEAS has no effect on it.

Key words: transcutaneous electrical acupoint stimulation , dynorphin, breast cancer