关键词: 中性粒细胞淋巴细胞百分比, 乳腺癌, 总体生存, 无病生存

Abstract: 【Abstract】 Objective The neutrophil lymphocyte ratio（NLR）was used as a easy parameter of systemic inflammation and immune status. The purpose was to investigate the clinical importance of preoperative NLR in patients with breast cancer. Methods We performed a retrospective analysis of 213 eligible patients diagnosed with primary breast cancer following radical surgery at Chancheng District Central Hospital of Foshan City. Clinicopathological parameters and survival status were investigated. The optimal cut?off value for NLR was obtained by receiver operating characteristics（ROC）analysis. Overall survival（OS）and disease?free survival（DFS）were assessed using the Kaplan?Meier method. Univariate and multivariate Cox regression model was performed to evaluate clinical parameters for their prognostic relevance. Results The optimal cut?off value was determined as 2.2 for NLR. Significant distribution differences were observed between the two groups in terms of histological grade,T stage,TNM stage. Patients in the elevated group（NLR≥2.2）showed significantly lower OS（5?year OS：59.6% vs 78.9%, P=0.001）and DFS（5?year DFS：56.7% vs 78.0%，P=0.002）. In addition，histological grade，T stage， NLR status and T stage,NLR status were independent prognostic factors for OS and DFS in our study respectively. Conclusion Our study suggested that preoperative NLR indicated poorer OS and DFS in patients with breast cancer following radical surgery. Further studies were required before it can be used for individual risk assessment.

Key words: overall survival, breast cancer, neutrophil lymphocyte ratio, disease?free survival