关键词: 临床病理特点, 青年乳腺癌, 临床预后

Abstract: 【Abstract】〓Objective〓To investigate clinicopathological characteristics of young breast cancer and its effect on clinical prognosis. Methods〓In this study, 85 cases of young breast cancer (≤35 years) in our hospital were treated as the youth group, 98 cases (>35 years) in the same period were recruited as the older group. The data, including clinicopathological characteristics, estrogen receptor (ER) and progesterone receptor (PR), Her-2 expression, P53 expression aspect, axillary lymph node metastasis and postoperative 5-year disease-free survival,were analyzed. Results〓There was no significant difference on pathological type, histological grade and clinical stage between the young and the older group (all P values >0.05). There was a significant difference on terms of estrogen receptor (ER), progesterone receptor (PR), Her-2 expression and axillary lymph node metastasis (all P values<0.05), except for P53 expression (P>0.05). The differences of postoperative 5-year disease-free survival in the two groups was statistically significant. Conclusion〓Young breast cancer has characteristics of more aggressive,earlier lymph node metastasis and lower postoperative 5-year disease-free survival compared to the older group, indicating that the early detection and standardized treatment is the best way to improve the prognosis.

Key words: Clinicopathological characteristics, Prognosis, Young breast cancer