关键词: DNA损伤修复基因, 结直肠癌, 肿瘤易感性, 遗传多态性, XRCC1

Abstract: 【Abstract】 Objective〓To explore the relationship between the polymorphism of X-ray cross complementing group 1 (XRCC1) Arg194Trp and genetic susceptibility of colorectal cancer (CRC). Methods〓All eligible case-control studies on the relationship between the polymorphism of the XRCC1 Arg194Trp and CRC in Chinese population were searched in both English and Chinese databases. Odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of this association. All analyses were conducted in Stata 12.0. Results〓A total of 11 case-control studies with 2710 cases and 3567 controls on XRCC1 Arg194Trp were included the Meta-analysis, and significant increased risks were found in additive models [(T vs C): OR (95%CI)=1.18 (1.01-1.39), P=0.036], homozygote comparison [(TT vs CC): OR (95%CI) =1.39 (1.02-1.90), P=0.038], Dominant models [(CT/TT vs CC): OR (95%CI) =2.24 (1.78-2.82), P<0.001], and recessive models [(TT vs CT/CC): OR (95%CI)=1.23 (1.02-1.49), P=0.030]. No publication bias was found in all genetic model. Conclusion〓In Chinese population, individuals carrying mutation allele T or homozygous mutation TT may have an increased risk of developing CRC, furthermore, individuals with the CT/TT genotype significantly increased the risk of suffering from CRC.

Key words: XRCC1, Cancer susceptibility, Colorectal cancer, Genetic polymorphism