关键词: 不良反应, 角度, 百白破疫苗

Abstract: 【Abstract】〓Objective〓To investigate the adverse reactions of diphtheria-pertussis-tetanus vaccine by muscle injection at less-than 90 degree of puncture. Methods〓This is a prospective study in which 933 with age feom 18 months to 24 months were divided in two groups, observation group (n=466) and control group (n=467). The vaccinee in observation group were treated by muscle injection at a vertical puncture way, while those in control group by muscle injection at less-than 90 degree of puncture way. The adverse reactions were recorded and analyzed. Results〓The adverse reactions occurred in 23 cases (23/466, 4.94%) in observation including fever in 11, and local red and swelling hard nodes induced by muscular injection in 12 cases. In control group, there were 44 cases of adverse reactions (44/467, 9.42%), fever in 24, and local red and swelling hard nodes induced by muscular injection in 20 cases. The difference between two groups had statistical significance(P=0.008). The FLACC scores in observation group were lower those in control group (P<0.05). Conclusion〓Carrying out the standard operating instructions of DPT vaccine is propitious to reduce the adverse reactions.

Key words: Adverse effecte, Diphtheria-pertussis-tetanus, Angle