关键词: 膀胱癌, PTEN, Beclin1, 免疫组化

Abstract: 【Abstract】〓Objective〓To investigate the expression of PTEN and Beclin1 in bladder cancer patients and to evaluate its clinical significance. Methods〓Immunohistochemical method was used to determine the expression of PTEN and Beclin1 in 65 cases of bladder cancer patients and the para-carcinoma tissues, and another 15 cases of normal bladder tissues. The relationship between PTEN and Beclin1 in cancer tissue was analyzed by Spearman correlation analysis. Results〓PTEN expression rate in cancer tissues,adjacent tissues and normal tissues were 53.8%,81.5% and 93.3%, respectively. Beclin1 high expression rate in cancer tissues,adjacent tissues and normal tissues were 58.5%, 84.6%and 86.7%, respectively. PTEN and Beclin1 high expression rate in cancer tissues were significantly higher than that of adjacent tissue and normal tissue (all P values were more than 0.05). PTEN and Beclin1 high expression rate in cancer tissues were correlated with histological grade and clinical staging of patients, regardless of patient gender and age. Beclin1 and PTEN expression decreased along with histological grade and clinical staging of patients increased, respectively (all P values were less than 0.05). Beclin1 expression was positively correlated with PTEN expression in cancer tissues (P<0.001). Conclusion〓The expression of PTEN and Beclin1 in bladder cancer were associated with tumor occurrence, progression.

Key words: PTEN, Beclin1, Immunohistochemistry, Bladder cancer