关键词: 阿片物质, 血管新生, 乳腺癌, 休眠

Abstract: 【Abstract】〓The incidence of breast cancer in our country is increasing in recent years. Surgical treatment occupies an important position in the comprehensive therapy of breast cancer,resulting in the use of perioperative analgesic drugs. Opioids are widely used in the perioperative analgesic and a variety of pain treatment, including cancerous pain. Opioids play an irreplaceable role in analgesia, so the use of opioids in the process of treatment is inevitable. However, the study found that opioids may affect breast cancer angiogenesis, tumor dormancy, recurrence and metastasis, which may affect the outcome of patients with breast cancer. Therefore, the effects of opioids on tumor recurrence and metastasis in patients with breast cancer cannot be ignored.

Key words: Opioid, Dormancy , Breast cancer, Angiogenesis