关键词: 超前镇痛, 炎性因子, 创伤, 临床效果

Abstract: 【Abstract】 Objective〓To investigate the clinical curative effect of preemptive analgesia combined multimodal analgesia on orthopaedic traumatic patients and the influence on serum level of inflammatory factors. Methods〓Ninety patients with bone and joint injury in our hospital were treated by surgery under combined spinal epidural anesthesia. According to the random number of the computer, the patients were divided into three groups, A group (conventional analgesia group,n=30), group B (preemptive analgesia combined multimodal analgesia group,n=30) and group C (multimodal group,n=30). Serum levels of inflammatory factors in the patients before and after operation, analgesic effect and adverse drug reactions were observed and analyzed. Results In group B, pain scores in 1 h after operation, 24 h, 48 h, 72 h were significantly lower than that of group A and group C, and the differences were statistically significant. Incidence of adverse reactions in B group were obviously lower than that in group A and group C (P<0.05). CPR level in postoperative 1 h, 24 h, 48 h in group A and group C were obviously higher than that of preoperative (P<0.05). CPR level of postoperative 24 h, 48 h in group B was lower than that in group A and group C (P<0.05). HCPR level of postoperative 1 h, 24 h in group B were significantly higher than those of preoperative level (P<0.05). Cor levels in three groups were significantly higher than the preoperative Cor levels, and which of group B and C were significantly higher than that of group A. Postoperative IL-6 levels in three groups were increased than the preoperative (P<0.05) and which in group B and C was lower than that in group A in postoperative 24 h, 48 h. IL-6 level in Group B in postoperative 24 h, 48 h were lower than that in group A and group C (P<0.05). The levels of IL-10 in group B in 1 h, 24 h, 48 h were lower than in geoup A and C. Conclusion〓Preemptive analgesia combined multimodal analgesia showed good clinical curative effect in orthopaedic traumatic patients.

Key words: Inflammatory cytokines , Truma, Preemptive analgesia, Clinical effect