关键词: 全身麻醉, 拔管期 , 艾贝宁

Abstract: 【Abstract】〓Objective〓To evaluate the effects of different doses of dexmedetomidine during tracheal extubation after general anesthesia. Methods〓Ninety cases of patients received radical hysterectomy surgery under general anesthesia were collected and divided into 3 groups (n=30 each), control group,low-dose group and high-dose group. The low-dose group received 0.3 μg/kg dexmedetomidine. The high-dose group received 1 μg/kg dexmedetomidine. The control group received the equal doses of saline. Hemodynamic changes, narcotrend value, recovery time and incidence of agitation were recorded during tracheal extubation after general anesthesia. Results〓Compared with control group, MAP of the patients in high-dose group were lower, recovery time were longer, incidence of agitation were lower(P<0.05). The hemodynamic changes of the low-dose group were more stable than the control group,the incidence of agitation were lower, recovery time and extubation time were shorter in low-dose group(P<0.05). Conclusion〓Low-dose dexmedetomidine for general anesthesia can effectively reduce extubation hemodynamic changes and incidence of agitation, and can shorten extubation time.

Key words: Dexmedetomidine, General anesthesia, Extubation