关键词: 苏醒期躁动, 小儿, 右美托咪定

Abstract: 【Abstract】〓Objective〓To investigate the effect of preoperative administration of single dose of demedetomidine on emergence agitation following sevoflurane anesthesia in small children undergoing laparoscopic hernia repair. Methods〓Sixty (ASA I-II, ageed 1-3 years) patients undergoing laparoscopic hernia repair, were assigned to three groups. Group D1 (n=20) received Dexmedetomidine 0.3 μg/kg iv immediately after induction over 10 mins. Group D2 (n=20) received Dexmedetomidine 0.5 μg/kg iv immediately after induction over 10 mins, whereas control group C(n=20) received equal volume of normal saline. Propofol (2000-4000 μg/kg) and cisatracurium (150-200 μg/kg) was used for induction and maintained. Results〓The agitation in the D2 group was lower than those in the control group. Mean Heart rate in dexmedetomidine group was found to be lower than in control group (P<0.05). Requirement of postoperative rescue drug was significantly lower in dexmedetomidine group. No significant difference was recorded in time to extubationin all three groups. Postoperative nausea and vomiting were not found in any subject in all the group. Conclusion〓Preoperative administration of 0.5 μg/kg of dexmedetomine is effective in reducing emergence agitation in small children following sevoflurane inhalation with no adverse effect.

Key words: Pediatrics, Dexmedetomidine, Emergence agitation