关键词: 乳腺肿瘤, 抗原, 趋化因子配体18, CCL18

Abstract: 【Abstract】〓Objective〓To research the expression of CCL18 in breast cancer and its association with prognosis of breast cancer. Methods〓Ninety-four tissue samples from patients with breast cancer were collected,.and 47 tissue samples with benign breast diseases were also collected. The control group contained 27 samples,which were collected from tissues aside the benign breast disease leisions..All of the cases were female..Envision immunohistochemical method was used to examine CL18, ER, PR, Her-2 and Ki67. All of the patients with breast cancer were followed-up for a mean of 39 months. Results〓Among patients with benign breast diseases and the control group, CCL18 was not found..While in the 94 patients with breast cancer,.CCL18 was found in 63 cases, positive ratio was 67.02%,and CCL18 was significantly up-regulated in breast cancer samples as compared with benign tumors or normal breast tissues(P<0.05)..Moreover,.the expression level of CCL18 was different according to the size of tumors,.the number of metastasized lymph node,.tumor stage, subtype of breast cancer, ER, PR, Her-2, and all of the differences were significant (P<0.05). High CCL18 expression was associated with poor disease-free survival and overall survival(both P<0.05). Conclusion〓CCL18 showed high expression in breast cancer,wirch was associated with poor prognosis and may serve as an independent prognostic marker for investigating breast cancer.

Key words: CCL18, Breast cancer, Antigen, Chemokine CC-motif ligand 18