关键词: IMPDH2, 前列腺癌, Gleason评分, Western Blot, 组织芯片

Abstract: 【Abstract】〓Objective〓To study the expression and significances of IMPDH2 in benign prostate hyperplasia (BPH) tissues and prostate cancer tissues, and to illustrate the correlation with clinical significance. Methods〓The samples were derived from benign prostatic tissue and prostatic carcinoma tissue of the patients with BPH or prostatic cancer. Western Blot was used to detect IMPDH2 protein in prostate cancer tissue and BPH tissue. Immunohistochemical method was used to detect IMPDH2 in prostate cancer tissue and BPH tissue,and evaluate the correlations with clinical significances of prostate cancer. Results〓The expression of IMPDH2 protein was significantly increased in prostate cancer tissues. The expression rate of IMPDH2 was in relation with clinical stage, Gleason score, and metastasis. Conclusion〓Our study showed the expression of IMPDH2 protein has positive correlation changed trend, suggesting IMPDH2 protein detection may help judge pathologic grade and predict the prognosis of prostate cancer.

Key words: IMPDH2, Prostate cancer, Gleason score, Western Blot, Tissue microarray