关键词: RKIP, 转移, 耐药, 预后因子

Abstract: 【Abstract】〓Raf kinase inhibitory protein (RKIP) was initially identified as phosphatidylethanolamine binding protein in bovine brain. Later RKIP has emerged as a critical molecule for regulating activation of MAPK, NF-κB and G protein coupled receptors (GPCRs). The disruption of RKIP in a wide range of pathologies, including cancer metastasis and therapeutic resistance makes it an exciting target for individualized therapy and disease-specific interventions. By combing clinical data analysis, RKIP became a new biological marker that reflects the prognosis of tumor. This review attempts to highlight recent advances in the RKIP field underscoring its potential role as a master modulator of many pivotal intracellular signaling cascades that control cancer metastasis and therapeutic resistance, and as a prognostic factor of tumor.

Key words: RKIP, Metastasis, Therapeutic resistance, Prognostic factor