关键词: 腰椎穿刺脑脊液置换术, 重型颅脑损伤, 蛛网膜下腔出血

Abstract: 【Abstract】〓Objective〓To investigate the lumbar puncture and cerebrospinal fluid replacement for treatment of traumatic brain injury with subarachnoid hemorrhage. Methods〓Fifty?鄄five cases of severe traumatic brain injury patients with subarachnoid hemorrhage underwent surgical treatment of lumbar puncture and cerebrospinal fluid replacement (observation group) from Jan 2012 to Mar 2014. Another 55 cases who received conventional treatment were chosen as control group. Bloody cerebrospinal fluid (BCSF) clearance time, complications, clinical efficacy were evaluated and compared between two groups. Results〓BCSF clearance time were 8.13±1.25 d, 9.37±1.49 d respectively in observation and control group and there was difference between two groups (P<0.05). Infarction, hydrocephalus, epilepsy incidence in observation group were 0, 1.82%, 3.64%, respectively and were 9.09%, 12.73%, 14.55% in control group(P<0.05). The rate of good by GOS score in observation group GOS was 52.73%, and 25.45% in control group (P<0.01). Severe disability rate, plant survival and mortality rates were 14.55%, 1.82%,0, respective in observation, and, 30.91%, 14.55%, 7.27% in control group (P<0.05). Conclusion〓Lumbar puncture and cerebrospinal fluid replacement therapy for severe traumatic brain injury with subarachnoid hemorrhage can reduce the incidence of complications, improve the prognosis.

Key words: Lumbar puncture and cerebrospinal fluid replacement, Severe brain injury, Subarachnoid hemorrhage