关键词: 糖皮质激素, 炎症性肠病, 并发症, 荟萃分析

Abstract: 【Abstract】〓Objective〓To investigate the relation between the risk factor of postoperative complications in patients with inflammatory bowel disease (IBD) and preoperative steroids usage, Methods〓We searched medical electronic database for full articles published since the year 1970 concerning postoperative complications in patients with IBD who undergone abdominal surgery. The perioperative patients with steroid or not were analyzed. Randomized effect or fixed effect was carried out depending on heterogenicity of the studies. Results〓A total of 28 retrospective studies met the inclusion criteria.Pooled analysis demonstrated an increased risk of total postoperative complications (OR=1.42, 95% CI: 1.61-1.75, P=0.0007) and infectious complications (OR=2.28, 95% CI: 1.49-3.49, P=0.0002) among patients using steroid preoperatively. Patients receiving higher dose of steroids (>20 mg/d) suffered from a higher risk of total complications (OR=1.45, 95% CI: 1.04-2.02, P=0.03) and infectious complications (OR=2.04, 95% CI: 1.05-3.95, P=0.04), compared with the lower group. Conclusion〓Total complications and infectious complications increased in IBD patients following preoperative steroid use after abdominal surgery. Preoperative dose of steroids under 20 mg/d could reduce this risk.

Key words: Steroid, Inflammatory bowel disease, Complication, Meta-analysis