关键词: 腹腔镜, 肺损伤, miRNA, 气腹, 缺血再灌注损伤

Abstract: 【Abstract】〓Laparoscopic surgery has developed rapidly in recent years as a crucial component of minimally invasive surgery,with the characteristics of lower trauma and faster recovery. Nevertheless the high intra-abdominal pressure and acid-base balance disorder caused by CO2 pneumoperitoneum can damage lung tissue,result in postoperative pulmonary dysfunction,even respiratory failure in severe patients..MiRNA is a kind of small noncoding regulatory RNA,.acted as a regulating role in multiple life process..Studies show miRNA is connected closely with the occurrence、development and outcome of all sorts of lung diseases..With the maturity and popularity of laparoscopic technique,.lung injury after laparoscopic surgery becomes highlighted increasingly..Thus a better exploration and understanding of its mechanism and the role miRNA plays can be helpful to the clinical diagnosis and treatment. This article will make a review of the mechanism of lung injury after laparoscopic surgery as well as the potential role miRNA plays in it.

Key words: Laparoscopy, Lung injury, MiRNA, Pneumoperitoneum, Ischemia-reperfusion injury