关键词: 原发乳腺癌, 前哨淋巴结活检术, 非前哨淋巴结转移, 预测因子

Abstract:

【Abstract】 Objective〓To investigate the predictable factors of metastasis in non sentinel lymph nodes (NSLN) in patients with prime breast cancer with positive sentinel lymph nodes (SLN). Methods〓Patients with primary breast cancer and positive sentinel lymph node (n=212) were included in this retrospective study.All patients had positive SLNs that had been ordered by the concentration of tracer,and were analyzed to determine factors that predicted additional positive axillary nodes. Pearson Chi-square or T-test were used for univariate analysis. Logistic regression was used for multivariate analysis..Results〓Of 212 breast cancer patients with positive sentinel lymph node ranked by the concentration of tracer, multivariate analysis revealed that NSLN was associated with the SLN metastases rate (P<0.001), the number of negative SLN (P=0.02), metastases in the latest lymph node (P=0.02) and the size of SLN metastases (P<0.001) which independently predicted the NSLN metastases. Conclusion〓SLNs with higher concentration of tracer might have higher possibility of metastasis. Our study suggested that the SLN metastases rate, the number of negative SLN, metastases in the latest lymph node and the size of SLN metastases independently associated with NSLN metastasis.

Key words: Primary breast cancer, SLN, NSLN metastases, Predictors