关键词: 严重腹腔感染, 重症监护病房, 经验性治疗, 病原菌, 抗菌药物

Abstract: 【Abstract】〓Objective〓To investigate the distribution and antibiotic resistance of clinical pathogen isolated from patients of intra abdominal infection associated sepsis in surgical intensive care unit (SICU) of our hospital, then instruct clinical application of antibiotics reasonably. Methods〓The clinical data of sIAI patients in our ICU from January 2012 to December 2013 were retrospectively analyzed. All the specimens were analyzed for pathogen distribution and drug susceptibility. Results〓A total of 151 strains of pathogenic bacteria was isolated, in which Gram-negative bacteria were the most popular pathogen (126 strains, 70.79%), among which escherichia coli was dominant, whereas Gram-positive bacteria accounted for 20.79% (39 strains), among which enterococcus faecium was the predominant species; and fungi accounted for 8.42% (13 strains). Of the 58 patients with sIAS, the mixed infections accounted for 89.66%. The rate of the ESBL-producing strains of escherichia coli and pneumonia were 67.50% and 57.25%. Both of them showed low resistance to carbapenem antibiotics. Conclusion〓Gram-negative bacteria were the most popular pathogen of the sIAI patients. The mixed infections rates and the resistance of the pathogen isolated from the patients are seriously high. Early and rational using of antibiotics is of great importance to control the production and transmission of drug resistance.

Key words: Intensive care units, Severe intra-abdominal infection, Empirical treatment, Pathogen, Anti-bacterial agents