关键词: 萘普生钠, 舒芬太尼, 上肢, 静脉镇痛

Abstract: 【Abstract】〓Objective〓To evaluate the analgesia effect of patient controlled intravenous analgesia (PCIA) with naproxen sodium and sufentanil in upper extremity surgery. Methods〓Ninety patients with ASA Ⅰ-Ⅱ that were scheduled for clavicular and upper extremity surgery under brachial plexus retardation, and treated with PCIA after the surgery. The patients were randomized into three group, fentanyl group (Group F, n=30), sufentanil group (group SF,n=30) and naproxen sodium+sufentanil group (group SF+N, n=30). PCIA gradients used for each group are as follow: fentanyl 20 μg/kg+ondansetron hydrochloride 0.15 mg/kg for group F, sufentanil 2.0 μg/kg+naproxen sodium 0.15 mg/kg for group SF; Sufentanil 1.5 μg/kg+ naproxen sodium 10 mg/kg+ondansetron hydrochloride 0.15 mg/kg for group SF+N,which were diluted to be 100 ml by adding saline. VAS, Ramesy scores and pressing times of PCA equipment,side effects as well as patient's satisfactory degree were recorded and compared among 3 groups. Results〓There was no significant difference in pressing times of PCA equipment..And SF+N group showed no significant different outcome regarding to the VAS score, Ramesy score and when compared with group F and group SF (P>0.05). Group SF+N showed significantly higher satisfactory degree as compared to group F and group SF (P<0.05). Conclusion〓Naproxen sodium combining with sufentanil in PCIA exhibits better clinical effect with less side effects and higher satisfactory degree for patients.

Key words: Naproxen sodium, Sufentanil, Upper extremity, Intravenous analgesia