关键词: 雷奈酸锶, 男性骨质疏松症, 骨痛, 骨密度

Abstract: 【Abstract】〓Objective〓To evaluate the efficacy and safety of strontium ranelate on bone pain during the treatment for male osteoporosis. Methods〓Fifty-eight elderly osteoporosis men were divided into strontium ranelate group (SR group, 26 cases) and calcium group (control group, 32 cases). Visualanalog scale (VAS) scores of the lumbar and back pain, bone mineral density (BMD) and T scores of the lumbar vertebra 1-4 and the Ward's triangle were determined. The incidence of osteoporotic fracture and side effects after drug treatment in both groups were also observed. Results The VAS scores in SR group were obviously improved,and were lower than those in control group (P<0.001). The BMD values of the lumbar venebra1-4 and Ward's triangle significantly increased in SR group after treatment compared to those before the treatment,.and the curative effects of strontium ranelate on SR group was obviously better than effects of calcium on control group (P<0.001). The adverse events were nausea and vomiting and erythra in SR group, and constipation in control group. Conclusion〓Strontium ranelate can effectively improve bone mineral density and ameliorate the chronic low back pain, which is a remarkable treatment for male patients with primary osteoporosis.

Key words: Strontium ranelate, Male osteoporosis, Bone pain, Bone mineral density