关键词: 冠脉搭桥术, 体外循环, 急性肾损伤, 危险因素, 预后

Abstract: 【Abstract】〓Objective〓To investigate risk factors and short-term outcomes of acute kidney injury (AKI).following CABG with extracorporeal circulation...Methods AKI was defined as relative 50% increase or an absolute increment of 26.4 umol/L in Scr within 48 hours and/or urine volume <0.5 ml·kg-1·h-1 up to 6h..According to the definition of AKI,.189 patients who received on-pump CABG from January 2007 to October 2013 were divided into acute renal injury group (AKI group, n=18) and non acute renal injury group(non AKI group,.n=171),.and were compared with clinical characteristics, complications and mortality. Results〓The incidence of AKI was 9.5% (18 cases). In-hospital mortality of AKI group was 22.2%, which was significantly higher than that of non-AKI group vs. (3.5%, P<0.05). Age in AKI group (70.22±9.52) was significantly higher than that in non-AKI group (vs. 63.94±10.79, P=0.019), as was Diabetes mellitus 55.6% vs 30.9% (P=0.035), hypertention 88.9% vs 62.7% (P=0.026), chronic obstructive pulmonary disease 11.1% vs 0.6% (P=0.024), EuroSCORE (The European System for Cardiac Operative Risk Evaluation) 5.94±3.09 vs 3.84±2.52 (P=0.002), extracorporeal circula-tion time 110.33±42.64 min vs 90.39±30.39 min(P=0.012),.with IABP 22.2% vs 7.1% (P=0.028), and postoperative glomerular filtration rate 31.10±15.20 vs 67.4±23.45 mL·min-1·1.73 m-2(P<0.001). Conclusion〓Age, Diabetes mellitus, hypertention, chronic obstructive pulmonary disease, EuroSCORE, extracorporeal circulation time, with IABP were risk factors of post-operative AKI for patients undergoing CABG with extracorporeal circulation. AKI was associated with higher mortality rate.

Key words: Coronary artery bypass grafting surgery, Extracoporeal circulation, Acute kidney injury, Risk factor, Prognosis