关键词: Tau蛋白, 复发转移, 乳腺癌, 紫杉醇

Abstract: 【Abstract】〓Objective〓To investigate the expression of Tau protein in recurrent and metastatic breast cancer and the correlation between Tau protein and the effect of taxane-containing palliative chemotherapy. Methods〓The expression of Tao protein in the metastatic breast tumor tissue of 136 patients with recurrent and metastatic breast cancer was detected by immunohistochemistry.The correlation between the expression of Tao protein and clinical variables, such as taxane sensitivity and the associations between Tau expression and the efficiency of taxane-containing palliative chemotherapy was used by χ2 test or Fisher exact probability test. Results〓The expression of Tau protein in thirty-nine (28.68%, 39/136) patients was positive. The expression of Tau protein was positively related to ER (P<0.05) and negatively related with the effect of taxanes-containing palliative chemotherapy (P<0.01). Conclusion〓The expression of Tau protein was negatively related with the effect of taxane-containing palliative chemotherapy. The detection of the expression of Tau protein in recurrent and metastatic breast cancer may be a clinical basis to choose taxane-containing palliative chemotherapy.

Key words: Tau protein, Recurrent and metastatic, Breast cancer, Taxane