关键词: 异时原发结直肠癌, 临床特点, 预后, 错配修饰基因

Abstract: 【Abstract】 Objective〓To investigate the clinical features of metachronous primary colorectal carcinomas. Methods〓From 2000 to 2012,19 cases of the clinical features and outcomes of metachronous colorectal carcinoma were retrospectively analyzed. Results〓In the 1304 cases of radical operation of colorectal carcinoma, the metachronous primary colorectal carcinoma were found in 19 cases during 2000 to 2012. The incidence rate of metachronous primary colorectal carcinoma was 1.4%. The metachronous cancer was confirmed in 15 to 135 months after operation of primary colorectal cancer (mean 77 months and 74.2±29.5 months on average). 68.4% of the metachronous carcinomas were found in 5 years after first operation. Compared with the initial carcinomas, the metachronous carcinomas showed smaller mass in size and more located in the ascending colon. 78.6% of the patients had deficiency of mismatching modification gene protein expression. The 5-years survival rate was 94.7%. All patients were without lymphatic metastasis and blood metastasis. Conclusion〓Metachronous primary colon carcinomas is low in incidence rate, but it has a higher mismatching maodification gene and with better prognosis.

Key words: Metachronous colorectal carcinomas, Clinical feature, Prognosis, Mismatch modified genes