关键词: ω-3鱼油脂肪乳剂;肠梗阻;肠粘膜通透性;菌群移位

Abstract: 【Abstract】 Objective To investigate the effect of ω-3 fish oil emulsion on intestinal permeability and bacterial translocation. Methods Ninety patients with intestinal obstruction were randomized into treatment group and controls. Controls received conventional treatment, including fasting, gastrointestinal decompression, correcting water electrolyte and acid-base balance disorders, parenteral nutrition and antibiotics. Treatment group used ω-3 fish oil emulsion on the basis of conventional therapy. Peripheral blood were collected for detection of routine serum biochemical, plasma glutamate (Gln) concentration and bacterial DNA. Meanwhile, urinary lactulose/mannitol (L/M) ratio was measured. The indexes above were compared between two groups. Results Serum albumin, serum prealbumin, serum transferrin in both groups increased higher significantly (P<0.05) while blood glucose was obviously lower (P<0.05). In the control group, IgA of the late course decreased sharply than the earlier(P<0.05), but there was no significant change in the treatment group. Plasma ω-3 fish oil emulsion concentrations in the treatment group was higher (P<0.01) than the control group,but the urinary lactulose/mannitol (L/M) ratio in the late course and the positive rate of bacterial DNA in peripheral blood were lower than that in control group (P<0.01). Conclusions ω-3 fish oil emulsion plays an important role in maintaining gut barrier function in patients with intestinal obstruction, at the same time, it can reduce bacterial translocation and complications.

Key words: ω-3 fish oil emulsion, Intestinal obstruction, Intestinal permeability, Bacterial translocation