关键词: 右美托咪啶, Flotrac/Vigileo 系统, 血流动力学变化

Abstract: 【Abstract】 Objective To observe the hemodynamic impact of loading dose of dexmedetomidine by Flotrac/Vigileo system monitoring. Methods Sixty patients scheduled for elective endourethral surgery under combined spinal-epidural anesthesia were randomized into two groups(group Dex and group Con). Group dex was infused dexmedetomidine as a loading dose of 0.5 μg/kg for 10min after spinal anesthesia blockage level stablized, while group Con received normal saline placebo infusion. The hemodynamic parameters were monitored by Flotrac/Vigileo system. Heart rate (HR), mean arterial pressure (MAP), cardiac output (CO), cardiac index (CI) and central venous pressure (CVP) were monitored. Systemic vascular resistance (SVR) was calculated in vigileo monitor and blood lactate was measure by blood gas analysis. Above parameters were recorded before anesthesia, after the level of anesthesia stable, and 1 min, 3 min, 5 min, 7 min, 10 min, 30 min after dexmedetomidine infusion. Results Compared with group Con, SVR decreased and CVP increased significantly 1 min after infusion in group Dex (P<0.05). CO and CI decreased 5min after infusion (P<0.05). MAP decreased 7 min after infusion (P<0.05). HR decreased 10 min after infusion (P<0.05). Conclusion Loading dose of dexmedetomidine slightly depressed MAP,.HR,.CO and SVR,.and increased CVP as well. Flotrac/Vigileo hemodynamic monitoring could reveal the hemodynamic changes earlier.

Key words: Dexmedetomidine, Flotrac/Vigileo system, Hemodynamic changes