关键词: FAP-1, 肝细胞肝癌, 预后

Abstract:

【Abstract】 Objective To investigate the expression of FAP-1 in hepatocellular carcinoma (HCC) and its clinical significance. Methods Immunohistochemistry was used to detect the expression of FAP-1 in primary tumor tissue of 66 patients with HCC and the expression levels were analyzed in combination with the clinicopathologic variables of HCC. Results Up regulation of FAP-1 protein expression was correlated strongly with TNM stage,tumor number and tumor recurrence.FAP-1 negative expression patients showed a significantly better prognosis than the FAP-1 positive patients. Multivariate analysis showed that FAP-1 expression, vascular invasion, tumor size, and TNM stage were significant independent variables for survival. Conclusion The expression of FAP-1 in HCC would affect pathologic feature of liver cancer cells and further affect the prognosis of patients with liver cancer.

Key words: FAP-1, Hepatocellular carcinoma, Prognosis