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Abstract:

【Abstract】Objective To investigate the differential expressions of vacuolar protein sorting 4 (Vps4)between HCC tissues and adjacent noncancerous tissues and to explore the clinical significance of Vps4 expression. Methods The expressional levels of Vps4 were detected using three step method of immunohistochemistry in 56 pairs of HCC tissues and adjacent noncancerous tissues who underwent surgical excision and were pathologically diagnosed as HCC, and the 11 normal liver tissues were also detected by the same method. Results 1) Vps4 can be expressed in HCC tissues,noncancerous tissues, normal liver tissues, bile duct tumor thrombi,vascular thrombi and metastatic lymph nodes. 2)Vps4 expressed more in adjacent noncancerous tissues than in HCC tissues.Vps4 also expressed more in normal liver tissues than in HCC tissues. Both of the difference were statistically significant (P<0.05). Vps4 expressed in adjacent noncancerous tissues and normal liver tissues were no statistical significance(P>0.05). 3) Vps4 expression was correlated with HBV-DNA copies. Conclusion Vps4 were expressed significantly different between HCC tissues and noncancerous tissues,and it was related with HBV-DNA copies, it may be involved in the genesis and the development of HCC.

Key words: Vps4, HCC, Immunohistochemistry