关键词: 胰腺癌;miR-146a;临床病理特征

Abstract:

【Abstract】Objective To investigate the expression of miRNA-146a in the pancreatic cancer and pancreas benign lesions tissues and evaluate the clinical significance and applied value of miRNA-146a expression in pancreatic cancer. Methods Fourteen cases with pancreatic cancer were included in this study. The tissues were collected from every pancreatic cancer patient after pancreticoduodenectomy. Six pancreatic benign lesions tissues were used as controls. The Agilent Human miRNA Microarray (V12.0) was used to screen miR-146a different expression in the 20 samples, and its relationship with clinic pathological features was analyzed. Results The expression of miRNA-146a in pancreatic cancer was significantly higher than that in pancreatic benign lesions (P<0.001). There were no significant correlations between the expression of miRNA-146a and age, gender, smoking status, tumor stage, lymph node metastases, distant metastasis, tumor differentiation, nerve invasion, vessel invasion and the level of serum CA19-9 (P>0.05). Conclusions Upregatation of miR-146a in the pancreatic cancer suggests that it may be involved in tumourgenesis of panckeatic cancer. miR-146a may become a novel tumormarker or prognostic factor for pancreatic cancer.

Key words: Pancreatic cancer, microRNA-146a, Clinicopathologic characteristics