关键词: 艾滋病, 封闭式负压引流术, Bax蛋白, Bcl-2蛋白

Abstract: 【Abstract】〓Objective〓To investigate the expression of Bax and Bcl-2 protein in the wound tissues in AIDS paitents and the effect of vacuum-assisted closure(VAC) on wound healing. Methods〓Forty AiDS patients with infective wound were selected and divided VAC treatment group (VAC group, n=20) and conventional dressing therapy group (control group, n=20). Bax and Bcl-2 protein expression were determined before treatment and in 3,7 and 14 days after different treatment, respectively. Results〓The VAC group had obvious healing effect, including the markedly effective in 17 cases, the effective in 2 cases, the ineffective in one, while the markedly effective was in 3 cases,the effective in 14 cases,the ineffective in 3 cases in conventional treatment group. There were no significant differences in Bcl-2 protein expression between two groups before treatment (P>0.05). Bcl-2 expression was increased significantly in VAC group than that in control group in 3,7,14 days after treatment(P<0.01). There were no significant differences in Bax protein expression between two groups before treatment, but level of Bax expression in VAC group was significantly lower than that in control group in 3,7,14 days after treatment(P<0.01). Conclusion In the present study, VA C treatment promoted wound healing in AIDS patients, which was associated with. Bcl-2 protein up-regulation and Bax down-regulation.

Key words: Vacuum-Assisted Closure, AIDS, Bax protein, Bcl-2 protein